Infertility is a serious globe issue, especially in the developed countries, over 20infertile male has sperm problems, that include instance immotile, abnormal morphologylow sperm quantity. Therefore, how to isolate high quality sperm for clinical use is extremely required. Up to date, activity sperm sorting is usually using Swiming-upDensity gradient centrifugation approaches. Unfortunately, both methods are detrimental to the sperm viabilityelicits production of reactive oxygen species. Separation sperm by microfluidics has been put emphasis onstudied however, it faced some challenge such as low throughputan unacceptable recover rate.

With the development of photonics, there has been a push towards optoelectronic devices that are flexible, rollable, wearable, user-friendly,robust to improve human-machine interfaces. To be integrated onto human body, these devices must be biocompatiblebe able to withstand mechanical deformationdifferent bending curvatures. Figure 1 shows the rollablesoft photonic meta-device.

We present pen-probe analyzers based on ion-mobility spectrometry and mass spectrometry for in-situ detection of volatile organic compounds (VOCs) or mapping of VOCs emanating from surfaces. User approaches probe to the analyzed object, and presses a button on the probe. The collected data are uploaded to the Internet cloud for retrieval and processing. Every data file contains the exact time and geographical co-ordinates of sample collection site. In another embodiment, the pen-shaped probe has been robotized to enable open-space sampling and mapping of VOCs emanating from solid specimens.

By implementing machine learning architecture with a convolutional neural network, we illustrate a fast, robust, and precise quantum state tomography for continuous variables, through the experimentally measured data generated from the balanced homodyne detectors. Compared with the time consuming MLE method, demonstrations on the reconstruction of Wigner function and the corresponding density matrix are illustrated for squeezed vacuum states in less than one second, keeping the fidelity up to 0.99 even taking 20 dB anti-squeezing level into consideration. Our neural network enhanced quantum state tomography provides the metrics to give physical descriptions of every feature observed in the quantum state and paves a way of exploring large-scale quantum systems.

A small organic molecule with multiple redox-active sites shows promise in the development of next-generation electric energy storage systems, especially for electric cars, green energy, and large-scale energy storage, when used as an active materials in a cathode in lithium-ion batteries (LIBs). Herein, an organic LIB with cathode material based on hexaazatriphenylene embedded quinone exhibits high capacity, high rate capability, and high cycling stability, which are far superior to that of commercial LIBs.

1. The modular design of a electric breaker is proposed. A prototype of a solid-state circuit with an input voltage of 500 V and adjustable rated current including 50 A, 100 A, 150 A and 200 A. 2. Achieved zero-current cutoff within 110 µs using the characteristics of IGBTs to detect the current value. 3. A12 bits analog/digital converter is used to achieve a higher accuracy current detection effect when compared with the conventional analog circuit. It can also detect the fault current rising rate and correspond to different protection delay times according to the different fault current rising rate, so that the components in the solid-state breaker can withstand a lower fault current.

Nano-sized silicon reacts rapidly with most water solutions to form pure hydrogen. However, high cost and low availability are major issue. Our group has developed novel nano-sized silicon mass-production process, greatly improves its feasibility and cost for hydrogen generation. The in-time hydrogen generation by nano-size silicon, fuel-cell system and lithium ion battery system are all well integrated into one portable power system, which can satisfy general personnel electricity demand for some special conditions, such as battle field, emergency case and remote regions.

1.Real-time monitoring of air quality in indooroutdoor environments: Sensors based on laser light scatteringelectrochemistry are used for monitoring PM2.5other air pollutants in indooroutdoor environments. The collected data from the sensors are transferred to the data center at NTU PHRC by 4G LTE. The residents can obtain the real-time air quality information through the website.2. Precision Prevention Application: an APP of CVD Risk Prediction:We developed an application for predicting CVD risk based on a Bayesian predicting model with personalized factors. With the precision risk of CVD, the health care workers can provide personalized suggestion for patients.

1. Demonstrate Virtual Manufacturing/AR/VR technology, integrate product designprocess planning processes (simultaneous engineering).2. 3D printing design system: Utillized Rhinos built-in calculation editor Grasshopperinfinite element method to generate complex lattice microstructures. The lattices model could directly transfer to all types additive manufacturing machine to fabricate the designs, allowing for rapid prototypinglattices shapes iteration.

High entropy materials were proposeddeveloped by Professor Jien-Wei Yeh in 1995. He named, defined,elucidated “High-Entropy Alloys,” as well as established High-Entropy Materials Center to develop critical materials for smart machine, green technology, biomedical technology,national defense. Alloys with high strength, corrosion resistance,anti-bacterial capability are also developed for manufacturing knives, door handles, handrails, etc. to prevent infection during the post-epidemic era.

We develop a test for discriminationapply it to analyze the change in income distributions between femalemale. We then classify our data into marriedsingle groups to trace the sources of income differences between femalemale from 2005 to 2015.

1. Identification of host factor, which is required for virus replication, by “EditCell Virology Platform”.2. The host factor will be as a target to develop antivirals.3. The antiviral effects of the candidates can be validated in vitroin vivo.4. Two FDA-approved drugs are repurposed for COVID-19 treatment.

After a period of strict quarantine, these animals are continuously screened with the twin goals of finding specific pathogen-free shrimp seeds while maintaining genetic diversity. The best representatives of these two sub-goals are then selected for production at our commercial P. monodon shrimp seed expansion site in Hualien.

The technology designs a modular friction stir welding tool holder. This welding tool holder integrates a variety of functions, including constant pressure welding, temperature monitoring, removable FSW tool design, and can be clamped to an existing CNCmachine. The advantage is that it can realize the function of automatic exchange for friction stir welding and CNC milling in one machine. Breaking through the previous friction stir welding, you need to buy a friction stir welding machine, which is expensive to obtain.

AI is applied to assist data cleaning and cross-database authority control of names and institutions in the bibliographic materials such as patents, papers and research projects.

This study proposes a 5G C-V2I (Cellular Vehicle-to-Infrastructure) enabled intelligent trajectory predictionwarning system, which can be implemented in a framework including RSUs (Road Side Units) with radar detection ability5G edge computing servers. This study exploits artificial intelligence to predict instant trajectories of vehicles at crossroads. The resulting augmented-awareness navigation information is then broadcasted to road users through 5G C-V2I with low latency. In practical applications, road users can obtain real-time dynamics of surrounding vehicles so that their level of safety can be effectively enhanced.

Surface-enhanced Raman spectroscopy (SERS) is a useful analytical technique for detecting extremely small amounts of molecules. Herein, we designed a paper-based quasi-three-dimensional SERS substrate (P-SERS) that can provide potential to improve Raman analyses for food safety, pesticide poisoning, precision medicine, drug abuseDNA/RNA testing. The sensitive, low-cost, flexibledisposable SERS substrate could be easily fabricated by physical deposition of gold nanoparticles array onto a filter paper. In this case, we are able to create non-continuous Au islands on the fiber surfaces, where the gaps between AuNPs can dramatically generate the high electric field to enhance Raman signal of target molecules.

Electroplated nanotwinned Cu possesses excellent electrical & mechanical properties. It can be applied in three major joints:1. Low thermal budget/ low resistance Cu bonding for high performance computing chip.We are able to achieve low temperature bondinginstant bonding. Low temperature bonding is performed at 150°C for 1 h to achieve low contact resistance copper bonding. Instant bonding is performed at 300°C for 5 seconds under a pressure of 90MPa achieve low contact resistance.2. High strength/ High ductility copper lines in 3D-IC packaging We are able to fabricate high strength foils with tensile strength of 800MPa. After annealing at 150°C for 3 hours, the foil retains a tensile strength of 750MPa. 3. Cu foils for lithium ion battery

Based on deep learning camera/radar object detection and tracking technology, the proposed road side unit (RSU) system has achieved over 95％ vehicle detection accuracy within 100m detection range in the processing performance of 10fps under nVidia Jetson Xavier platform. Compared to the 32-beam lidar based RSU, the proposed RSU achieves 97％ reduction of sensor cost that exhibits high competitiveness in deployment cost. The proposed RSU system has been verified in fields and we are now cooperating with an industry partner to deploy the RSU system in both Tainan and Tao-Yuan cities.

Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) recombinant antigen A1 inhibits the expression of CD163 on the cell surface by inducing the polarization of M1 macrophage subset, which can further effectively reduce virus invasion and viral infection. A1 can regulate the endogenous genes of alveolar macrophages to activate Th1-type immune response and enhance cellular immunity. Therefore, this technical invention will be beneficial to screen the new generation of PRRSV candidate structural vaccines.

The technology combines specific visual recognition and electrochemical quantitative detection in a single portable device, providing instant and convenient copper ion detection. The sensing sensitivity has reached the standards of Taiwan and the United States for heavy metal detection for food, human body, and environments. In use, this portable and user-friendly interface device not only makes it simple to report back to the EPA database for water quality analysis, but also it can be utilized for real-time detection from youngsters to the elderly.

Due to the recent outbreak of COVID-19 and ongoing mutants, we developed a coronavirus variant protein microarray that includes all the current spike mutations and the wild-type viral antigens and applied in detecting immune responses and drug specificities. We filed the patients and published our findings in the Analytical Chemistry. Besides massive production of the coronavirus protein microarray, we also collaborated with a scanner company, developed artificial intelligence software, and collaborated with suppliers. We are welcome any sort of collaboration.

Our PEDD has been used to detect the HNE level in both tear and wound fluids of 9 patients, and the limitations of detection were about 0.76 μg/mL and 0.63 μg/mL respectively. Our device requires only 15 minutes, 3 μL of clinical sample for each test, and offers superior sensitivity compared to other current HNE detection methods. The HNE concentrations in the patient samples have shown that the elevated HNE levels might suggest an abnormal healing of either acute or chronic wounds, consistent with previous studies that showed excess protease levels in all non-healing wounds.

A virus NT was performed in a biosafety level 3 laboratory to determine the titers. A SARS-CoV-2 enzyme-linked immunosorbent assay (ELISA) was designed to detect neutralizing antibodies in the serum, based on the binding affinity of SARS-CoV-2 viral protein 1 and viral protein 2 to antibodies. ELISA results viral protein 1 and 2, generated comparable neutralizing antibody titers. The results analyzed by spline regression and two-variable generalized additive model precisely reflected the real NT value. Our method can serve as a surrogate to quantify neutralizing antibody titer.

The International Center for Wound Repair and Regeneration of National Cheng Kung University transferred and established Ducolege Biotechnology Co., Ltd., using Extre2Cold exclusive extraction technology to extract highly active marine collagen from Tilapia fish skin, which is type I collagen with a complete molecular structure and has a three-stranded helix structure. It is biologically active and perfectly presents the magical ability of fish skin to repair wounds. It can be widely used in biomedical materials and academic research. It is currently first promoted in the development of high-level medical beauty repair and maintenance products, which is helpful for repairing damaged skin.

The core generated several types of transgenic mice and a stable humanized ACE2 mice using a combi-CRISPR genetic engineering technique. We hope these mouse models can help to dissect COVID-19 pathogenic mechanism and the interaction(s) between spike protein and ACE2 K353.

This technology is used to reveal the immune profiling of the tumor microenvironment based on multi-color immunohistochemistry staining. Each immune cell type will be probed with different fluorophores. Density, as well as the location of each immune cell type on the tissue slides, will be disclosed using inForm software.

The "Viral Vaccine Cell Production Technology Platform" of this exhibition is based on 1. Host cellvirus matchcolonization technology 2. Cell-expressed virus receptor technology 3. Blocking antiviral mechanism of host cell 4. Immortalization technology of host cell 5. Serum-free suspension cell culture technology to produce high-immunity virus vaccine strains containing intact virus antigens.

This technology uses a customized high-resolution saltwater proof video camera that operates underwater for months on end without maintenance. The captured images are pre-processed to adjust the brightnessmaximize the sharpness, after which the images are input into a region-based convolutional neural networks (R-CNN) for trainingidentification. This technology is currently able to reliable identify shrimp in these imagesto distinguish between the shrimp’s headtail in order to conclude whether the image shows a complete shrimp.

SARS-CoV-2 IsolationWhole-genome Sequencing Analysis-The whole-genome sequencing was performed to examine 28 SARS-CoV-2 virus strains from patient tissue samples isolated by NTUH Department of Laboratory Medicine.2. Vh-chimera DNA as a New ctDNA Marker for Detecting the Existence of HBV-related HCC-About one-third of patients suffer tumor recurrence within the first year after surgical resection of HCCtheir overall survival is compromised. The study identified vh-chimera DNA as a novel ctDNA marker for HBV-related HCC detection.