Quantum Communication

e propose an AI dynamics drug repurposing platform applicate on COVID-19. This platform analyzed a large number of structures of SARS-CoV, MERS, and cross-species coronavirus 3CL protease-ligand complexes to construct uncovering six flexible active site conformations and pharmacophore clusters for SARS-CoV-2 3CL protease screening all FDA drugs and found four inhibitors within three months. Among them, JM206 had even demonstrated ten times better efficacy than Remdesivir in-vitro assay and also show the effect on the in-vivo hamster model to alleviate the symptoms caused by COVID-19.